Can Benadryl Cause A Positive Drug Test? | Why Screens Trip
Yes, diphenhydramine can trigger a false positive on some initial urine screens, most often methadone, until a lab runs confirmation testing. Benadryl is an over-the-counter antihistamine, not an illegal drug. That’s the plain truth. Still, some people take it for allergies, sleep, or a cold, then get rattled by an unexpected drug screen result. The
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